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Newsflash 2

Superficial Stromal Scar Formation Mechanism in Keratoconus

Peng Song, Shuting Wang, Peicheng Zhang,Wenjie Sui, Yangyang Zhang,
Ting Liu, and Hua Gao.


A Study Using Laser Scanning In Vivo Confocal Microscopy

 

Read more...

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan 250021, China.

 
 Study of Corneal Nerve Morphology In Unilateral KC
 
Corneal Nerves
 
To study the corneal nerve morphology and its importance in unilateral keratoconus
 
 
Narayana Nethralaya Eye Hospital, Bangalore, India.
Academic Hospital, Maastricht University, P.O.Box 616, 6200 MD Maastricht, The Netherlands.
 
Assessment of Macular Parameter Changes in KC Patients
Using Optical Coherence Tomography
 
Cut-away 3D view of the macula taken with the Optovue RTVue system
 
A Cut-away 3D view of the Macula taken with the Optovue RTVue System
 
'Therefore macular changes may relate to a more generalised disorganisation of the eye in
patients with keratoconus or a compensatory mechanism to
optimise acuity in eyes with irregular corneas.'

 
 
Srujana Sahebjada, Fakir M. Amirul Islam, Sanj Wickremasinghe, Mark Daniell, and Paul N. Baird, “Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography,” Journal of Ophthalmology, vol. 2015, Article ID 245953, 6 pages, 2015. doi:10.1155/2015/245953

Fortune Spins on a Small Pin Head

 Keratoconus management protocol based on the risk of progression
Management protocol based on the risk of progression
 
Current review and a simplified “five‑point management algorithm” for keratoconus
 
 
Shetty R, Kaweri L, Pahuja N, Nagaraja H, Wadia K, Jayadev C, et al.

CXL and Corneal Laser Surgery

Surgical Intervention
 
 

IROC Science to Innovation AG Stockerstrasse 37 CH- 8002 Zürich


RGX Corneal Crosslinking

One new development in collagen cross-linking technology is a method that uses green light to activate rose bengal, a well-known diagnostic agent for ocular surface damage.

This technology has already proven to be useful in sealing cornea wounds, bonding amniotic membrane to the corneal surface, and for applications in many other tissues [1-6].Cherfan et al. (2013) investigated whether photochemical cross-linking of the collagen in the corneal stroma using rose bengal and green light (a process referred to as RGX) increases corneal stiffness.

They investigated the processes involved and factors important for clinical application. It was revealed that RGX significantly increases corneal stiffness in a rapid treatment (approximately 12 minutes total time) by an oxygen-dependent mechanism. The approach does not cause toxicity to stromal keratocytes and may be used to stiffen corneas thinner than 400 μm. Therefore, RGX may provide an appealing approach to stiffen corneas for inhibiting progression of keratoconus and other ectatic disorders [7]

Read more...

[1] Gu, C. et al. Photochemical tissue bonding: a potential strategy for treating limbal stem cell deficiency. Lasers Surg Med. 2011 43(5):433-42.

[2] Henry, F. P. et al. Real-time in vivo assessment of the nerve microenvironment with coherent anti-Stokes Raman scattering microscopy. Plast Reconstr Surg. 2009;123(2 Suppl):123S-30S.


[3] O’Neill, A. C. et al. Microvascular anastomosis using a photochemical tissue bonding technique. Lasers Surg Med. 2007;39(9):716-22.

[4] Proaño, C. E. et al. Photochemical keratodesmos for bonding corneal incisions.Invest Ophthalmol Vis Sci. 2004;45(7):2177-81.

[5] Tsao, S. et al. Light-activated tissue bonding for excisional wound closure: a split-lesion clinical trial. Br J Dermatol. 2012;166(3):555-63.


[6] Verter, E. E. et al. Light-initiated bonding of amniotic membrane to cornea. Invest Ophthalmol Vis Sci. 2011;52(13):9470-7.

[7] Cherfan, D. et al. Collagen cross-linking using rose bengal and green light to increase corneal stiffness. Invest Ophthalmol Vis Sci. 2013;54(5):3426-33.

 


Results from CXL for Keratitis

Ryhov Hospital

Corneal Strengthening Procedure Also Has Antimicrobial Effects.

 

 Rapid improvement in symptoms and subsequent healing of the epithelium indicated that the treatment was a highly potent technique for the management of corneal infections - CRS Today.

 

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Department of Ophthalmology, Örebro University Hospital, and Ryhov County Hospital, Sweden

Hormonal Changes and Corneal Biomechanics

Corneal Topographical and Biomechanical Variations Associated with Hypothyroidism

 Z. Gatzioufas, G. Panos, E. Brugnolli, F. Hafezi


Case report: Corneal Biomechanics and Thyroid Hormones

tsh vs ch and crf

 

Read more...

Dept. of Ophthalmology, Geneva University Hospitals, Switzerland.

Analysis of Ocular Wavefront Aberrations Post Penetrating Keratoplasty

     

Adriana S. Forseto MD, Telma Pereira MD, Vera Mascaro MD, Lucila Pinto MD, Walton Nosé MD.

 

In Post Penetrating Keratoplasty Eyes

Two Different Hartmann-Shack Aberrometers Analysis of Ocular Wavefront Aberrations


Read more...

Eye Clinic Day Hospital. UNIFESPSão - Federal University of São Paulo Brazil.

 Scleral Lenses: Going Beyond the Corneal Borders

 

Shrinking the ‘giant’ with Science

 

Fernando Auza, O.D.

Managing Complex Irregular Corneas with Scleral Contact Lenses

 

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Centro Visual Santa Lucia, Bolivia.


Corneal Pachymetry and Confocal Microscopy

Sardar Patel Medical College 

Dr. Ram Singh

Sardar Patel Medical College

Corneal pachymetry is used to quantitatively measure cornea thickness, which is an important indication of the health and function of the cornea.

Confocal microscopy allows refractive surgeons and corneal specialists to actually look inside the living cornea and diagnose a variety of diseases. 

With this biomicroscope, the surgeon can see individual cells in each layer of the cornea in great detail. As a result, this technology can be used for pre operative assessment of corneal health; it can diagnose early signs of keratoconus and dry eye, it can assist in the evaluation of endothelial cell viability, it can be used to measure flap depth following LASIK, it can quantity LASIK interface healing quality and it can provide the surgeon with a view of the epithelial or surface layer to evaluate its overall health.

With very high magnification it is possible to see bacteria, fungi, inflammation and corneal dystrophies as well as tissue damage from drugs or contact lenses.

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Dept. of Ophthalmology, Sarder Patel Medical College, Bikaner, Rajasthan, India.


Standard Versus High Intensity CXL after Thermal Keratoplasty

CXL in Keraflex
 
Arthur Cummings M.B. Ch.B, MMed(Ophth), (Pret), F.C.S.(S.A), F.R.C.S.Ed
 

Timing CXL after Thermal Keratoplasty

 

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Wellington Eye Clinic and UPMC Beacon Hospital, Dublin, Ireland.


Corneal Biomechanics from Corneal Deformation Imaging

 Optical Group

Visual Optics and Biophotonics Lab

Susana Marcos, PhD

Corneal Imaging Applications to Crosslinking

 

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Instituto de Optica, CSIC, Madrid, Spain.

Keratoconus Research: That Which is Not Forbidden - is Mandatory

 

 Researching the Research

Research Warning : Not a religion, do not worship!

 

Alberto Arntz MD, Andrea Cruzat MD

Association between Corneal Diameter, Thickness and Keratometry

 

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Pontificia Universidad Católica de Chile.

Keratoconus - The Real Phantom Menace: Under Skin is Where He Hides

 

Thyroid Disfunction

The EndocrinologiststsPerspective

Zisis Gatzioufas, Berthold Seitz

 

Thyroid Gland Dysfunction and Keratoconus

 

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Department of Ophthalmology, University Hospital of Saarland, Kirrberger Strasse, D-66421 Homburg/Saar, Germany.

Treatment Paradigm for Keratoconus Remains Very Clear Cut

CXL & CL

The ContactlensologistsPerspective

Carina Koppen MD, PhD

Faculty of Medicine Associate Professor
 Department of Ophthalmology Senior Member

 

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Antwerp University Hospital, Belgium.


Keratoconus Promise: We Protect All Those Who Come to Our Domain

The Circle

Combined LASIK and Rapid-CXL in Suspicious Corneas 

 

Victor Derhartunian
Theo Seiler

Read more...


Institut für Refraktive und Ophthalmo-Chirurgie (IROC).


Power Under Control: Maximum Effect High Performance Optimization

Getting to you before its too late

Biomechanical Properties in Relation to Irradiation Intensity


Silvia Schumacher
Jeremy Wernli
Eberhard Spoerl


 

IROC AG, Zurich, Switzerland.
Augenklinik Universitätsklinikum Dresden, Dresden, Germany.


 They Start Where Others Stop: Breaking the Epithelium Barrier in Crosslinking

The Epi

Mechanical vs Laser Epithelium Removal During CXL

 
George D. Kymionis MD, PhD.
 

Institute of Vision and Optics Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.

The Visualization and Quantification Aspects of Evaluating the Anterior Segment Ocular Anatomy

Anterior Segment

Anterior Segment Analysis

Prof. Dr. Michael Mrochen

IROC AG

Read more...

 Institut für Refraktive und Ophthalmo-Chirurgie, Stockerstrasse 37, CH-8002 Zürich, Switzerland.


Under the Same Sun: The Recurrence of KC after Penetrating Keratoplasty Corneal Transplantation

Jenny Deva MD

Consultant Ophthalmologist & Contact Lens Specialist

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Read More

Tun Hussein Onn National Eye Hospital.
National Institute Of Ophthalmology.
Dept Of Molecular Biology, University Of Malaya.


 

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